Wily states that a machine he devised, capable of finding a cure for the illness, is stolen by an infected robot. The disease eventually causes many of the robots to malfunction and attempt to take over the world. Mega Man 10 takes place in the 21st century, in which a disease begins infecting and disabling robots, hampering daily life for humans.

It was later released again for a physical and digital release as part of Mega Man Legacy Collection 2 alongside Mega Man 7, Mega Man 8 and Mega Man 9 for the PlayStation 4, Xbox One, and Microsoft Windows, as well as the Nintendo Switch in May 2018. The game was also given a physical release along with four other Capcom titles from different franchises in the Capcom Essentials Pack for PlayStation 3 and Xbox 360. The game was released as a downloadable title for the console gaming services WiiWare, PlayStation Network (PSN), and Xbox Live Arcade (XBLA) during March 2010. It is the tenth main entry of the original Mega Man series. Mega Man 10 is an action- platform video game developed by Inti Creates and Capcom.

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